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KMID : 0861120160200010145
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Korean Journal of Oriental Preventive Medicine
2016 Volume.20 No. 1 p.145 ~ p.159
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Low Dose Effect and Non Monotonic Dose Responses(NMDRs) and its Medical Meaning - Focusing on A New Paradigm of Dose-Response Relationship -
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Sung Angela Dongmin
Shin Jee-Youn
Lee Seung-Eun
Park Song-Mi
Oh Yeon-Ji
Lee Sun-Dong
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Abstract
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Objectives : The aim was to investigate the characteristics of low dose effect and non monotonic dose responses(NMDRs) and to predict the influence it might have on the health and medicine, traditional Korean medicine.
Methods : By investigating recently published major literatures related to low dose effect and NMDRs, the definition, mechanism, major related fields, and the influence on public health and medicine has been categorized and summarized.
Results : Although there are still heated debates about the definition of low dose, it implies the biological responses in environmental exposure level and the NDMDRs means the nonlinear relationship between the dose-response in the slope sign change. Also, it implies the new form of the curve showing a U, reverse U shape, and the slop sign constantly changing showing various forms. This mechanism is because the two acceptor shows opposing effects to toxic materials and the affinity is different along with the numerical value that increase and decrease being different. These characteristics generally appear in endocrine disrupters such as bisphenol A, agricultural pesticides, metal, and radiation. The research field in the public health and medical treatment is obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause and phytoestrogen.
Conclusions : As a result of discussing implications, NMDRs is a particular effect in low dose and heated debates surround this response, research is being conducted surrounding the field of obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause, and phytoestrogen. More research and interest in needed as it can have a massive influence in the public health and medicine.
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KEYWORD
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low dose effect, dose response, non monotonic dose responses(NMDRs), Medicine, Korean medicine
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